(1997) Paul Boyer
Paul Delos Boyer is an American biochemist, analytical chemist. Boyer was born July 31, 1918 in Provo, Utah. He received a B.S. in chemistry from Brigham Young University in 1939 and obtained a Wisconsin Alumni Research Foundation Scholarship for graduate studies. After Boyer received his Ph.D. degree in biochemistry from the University of WisconsinâMadison in 1943, he spent years at Stanford University on a war-related research project dedicated to stabilization of serum albumin for transfusions. He began his independent research career at the University of Minnesota and introduced kinetic, isotopic, and chemical methods for investigating enzyme mechanisms. In 1955, he received a Guggenheim Fellowship and worked with Professor Hugo Theorell on the mechanism of alcohol dehydrogenase. Since 1963, he has been a Professor in the Department of Chemistry and Biochemistry at University of California, Los Angeles. In 1965, he became the Founding Director of the Molecular Biology Institute and spearheaded the construction of the building and the organization of an interdepartmental Ph.D. program. This institutional service did not diminish the creativity and originality of his research program, which led to three postulates for the binding mechanism for ATP synthesisâthat energy input was not used primarily to form ATP but to promote the binding of phosphate and mostly the release of tightly bound ATP; that three identical catalytic sites went through compulsory, sequential binding changes; and that the binding changes of the catalytic subunites, circularly arranged on the periphery of the enzyme, were driven by the rotation of a smaller internal subunit. He shared the 1997 Nobel Prize in Chemistry for research on the \"enzymatic mechanism underlying the biosynthesis of adenosine triphosphate (ATP)\" (ATP synthase) with John E. Walker; the remainder of the Prize in that year was awarded to Danish chemist Jens Christian Skou for his discovery of the Na+/K+-ATPase.
